Single- and mixed-metal nanoparticles, nanoparticle conjugates, devices for making nanoparticles, and related methods of use
AssigneeMontrose Biosystems LLC
InventorsJoseph P Dunham, Marcus Yaffee
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Abstract
Nanoparticles, nanoparticle conjugates, devices for making nanoparticles and nanoparticle conjugates, and related methods of use and synthesis are described.
Claims20
A nanoparticle comprising a solid metal core free, of ligands and non-metallic bonds, and further comprising an organic shell coupled to an outer surface of the solid metal core, wherein the organic shell further comprises a targeting moiety coupled to the nanoparticle, wherein the targeting moiety is configured to selectively bind to a target substrate.
A device for low-pressure, solution-phase synthesis of metal nanoparticles, the device comprising:
- a single Schlenk line assembly;
- an all-glass chemical reaction environment coupled to the single Schlenk line assembly, the all-glass chemical reaction environment comprising:
- a vacuum-stopped back pressure overload valve;
- a plurality of back pressure-loaded injectors;
- and
- a reaction vessel;
- and
- a tri-valved vacuum interface coupled to the single Schlenk line assembly and configured to provide an extended headspace maintained under low-pressure to establish a vapor-phase gradient in the reaction vessel.
A nanoparticle comprising a solid metal core free of ligands and non-metallic bonds, and further comprising an organic shell coupled to an outer surface of the solid metal core, wherein the organic shell further comprises a targeting moiety coupled to the nanoparticle, wherein the targeting moiety is configured to selectively bind to a target substrate, wherein the organic shell is coupled directly to the solid metal core, and wherein there is no ligand between the organic shell and the solid metal core.
A nanoparticle comprising a solid metal core free of ligands and non-metallic bonds, and further comprising an organic shell coupled to an outer surface of the solid metal core, wherein the organic shell further comprises a targeting moiety coupled to the nanoparticle, wherein the targeting moiety is configured to selectively bind to a target substrate, wherein the organic shell is coupled directly to the solid metal core, and wherein the outer surface of the solid metal core has a zero valence state.
Dependencies are inferred from the claim text.