Method of sealing a syringe barrel

A method of filling a syringe, comprising the steps of:

• providing a syringe barrel (6) having a syringe tip (64) at a distal end thereof on which a collar (4) for coupling with a syringe needle is mounted;
• filling a chamber of the syringe barrel (6) with a liquid containing a pharmaceutical drug;
• disposing a plunger within the chamber at an open proximal end thereof opposite to the distal end of the syringe barrel (6);
• sealing the syringe tip (64) with a resilient closure (5) so that the resilient closure (5) is seated on the syringe tip (64), said resilient closure (5) having a distal end (50);
• and
• providing a tamper evident syringe tip cap (1) comprising:
• a rigid outer cap having a cup-shaped distal cap member (2), formed by a first side wall extending in an axial direction as a cylindrical body and having a closed upper surface (20), for accommodating and covering the distal end (50) of the resilient closure (5),
• a proximal sleeve member (3) formed by a second side wall of the same outer diameter as the first side wall and extending in the axial direction, comprising a distal end (31) and a proximal end (30) and configured to be coupled with the collar (4) of the syringe barrel (60),
• an annular first breaking line (10), which extends perpendicularly to the axial direction of the tamper evident syringe tip cap (1), is formed between the distal cap member (2) and the proximal sleeve member (3) and comprises first frangible portions (11), and
• a second breaking line (35;
• 35a) extending between the distal end (31) and the proximal end (30) of the proximal sleeve member (3) in the second side wall and comprising second frangible portions (36), wherein
• the distal cap member (2) and the proximal sleeve member (3) are connected with each other via an axial coupling strip (29), which bridges and disrupts the annular first breaking line (10),
• the first frangible portions (11) and the second frangible portions (36) are weaker than the coupling strip (29), and
• a handling section comprising a step (25), which comprises a surface extending radially inward from the first side wall and perpendicular to or slanted relative to the axial direction and a vertical side wall (23) extending in the axial direction, and is formed in the first side wall of the distal cap member (2) opposite to a position where the axial coupling strip (29) bridges the annular first breaking line (10);
• and
• applying the tamper evident syringe tip cap (1) over the collar (4) and resilient closure (5) comprising:
• pushing the tamper evident syringe tip cap (1) in the axial direction on the distal end of the syringe barrel (6) until
• the proximal end (30) of the proximal sleeve member (3) is coupled with the collar (4), and
• the distal end (50) of the resilient closure (5) is accommodated in the cup-shaped distal cap member (2) and protrudes beyond the distal end (31) of the proximal sleeve member (3) but not so far that it would inhibit pivoting the cup-shaped distal cap member (2) about the coupling strip (29), wherein
• the cup-shaped distal cap member (2) is separated from the proximal sleeve member (3) of the rigid outer cap to break the first frangible portions (11) of the annular first breaking line (10) and partially separate the proximal sleeve member (3) from the rigid outer cap by pushing the vertical side wall (23) of the cup-shaped distal cap member (2) obliquely toward a distal end of the tamper evident syringe tip cap (1) and pivoting the cup-shaped distal cap member (2) about the coupling strip (29) while the resilient closure (5) remains seated on the syringe tip (64) to gain access to an upper surface (51) of the resilient closure (5), and
• the second frangible portions (36) of the second breaking line (35;
• 35a) are broken to completely tear off the tamper evident syringe tip cap (1) from the distal end of the syringe barrel (6) by further pivoting the cup-shaped distal cap member (2) about the coupling strip (29) and pulling down the cup-shaped distal cap member (2) towards the proximal end (30) of the proximal sleeve member (3).

A method of sealing a syringe barrel, comprising the steps of:

• providing the syringe barrel (6), said syringe barrel (6) having a syringe tip (64) at a distal end thereof on which a collar (4) for coupling with a syringe needle is mounted;
• sealing the syringe tip (64) with a resilient closure (5) so that the resilient closure (5) is seated on the syringe tip (64), said resilient closure (5) having a distal end (50);
• providing a tamper evident syringe tip cap (1) comprising:
• a rigid outer cap having a cup-shaped distal cap member (2), formed by a first side wall extending in an axial direction as a cylindrical body and having a closed upper surface (20), for accommodating and covering the distal end (50) of the resilient closure (5),
• a proximal sleeve member (3) formed by a second side wall of the same outer diameter as the first side wall as a cylindrical body and extending in the axial direction, comprising a distal end (31) and a proximal end (30) and configured to be coupled with the collar (4) of the syringe barrel (60),
• an annular first breaking line (10), which extends perpendicularly to an axial direction of the tamper evident syringe tip cap (1), is formed between the distal cap member (2) and the proximal sleeve member (3) and comprises first frangible portions (11), and
• a second breaking line (35;
• 35a) extending between the distal end (31) and the proximal end (30) of the proximal sleeve member (3) in the second side wall and comprising second frangible portions (36), wherein
• the distal cap member (2) and the proximal sleeve member (3) are connected with each other via an axial coupling strip (29), which bridges and disrupts the annular first breaking line (10), and
• the first frangible portions (11) and the second frangible portions (36) are weaker than the coupling strip (29);
• and
• applying the tamper evident syringe tip cap (1) over the collar (4) and resilient closure (5), comprising:
• pushing the tamper evident syringe tip cap (1) in the axial direction on the distal end of the syringe barrel (6)
• until the proximal end (30) of the proximal sleeve member (3) is coupled with the collar (4), and
• the distal end (50) of the resilient closure (5) is accommodated in the cup-shaped distal cap member (2) and protrudes beyond the distal end (31) of the proximal sleeve member (3) but not so far that it would inhibit pivoting the cup-shaped distal cap member (2) about the coupling strip (29), wherein
• the distal cap member (2) is separated from the proximal sleeve member (3) of the rigid outer cap to break the first frangible portions (11) of the annular first breaking line (10) and partially separate the proximal sleeve member (3) from the rigid outer cap by pushing the cup-shaped distal cap member (2) at a position opposite to a position where the axial coupling strip (29) bridges the annular first breaking line (10) obliquely toward a distal end of the tamper evident syringe tip cap (1) and pivoting the cup-shaped distal cap member (2) about the coupling strip (29) while the resilient closure (5) remains seated on the syringe tip (64) to gain access to an upper surface (51) of the resilient closure (5), and
• the second frangible portions (36) of the second breaking line (35;
• 35a) are broken to completely tear off the tamper evident syringe tip cap (1) from the distal end of the syringe barrel (6) by further pivoting the cup-shaped distal cap member (2) about the coupling strip (29) and pulling down the cup-shaped distal cap member (2) towards the proximal end (30) of the proximal sleeve member (3).