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US 12,296,054 B2Granted
Method of preparing polymeric microparticles, polymeric microparticles, medical composition, cosmetic composition, medical articles and cosmetic articles using the same
AssigneeLG Chem, Ltd.
InventorsYunseop Kim, Jung Youn Shin, Chanjoong Kim, Jee Seon Kim, Kyung Oh Kim, Je Young Ryu
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Abstract
According to the present disclosure, a method of preparing polymeric microparticles comprising further crosslinking with an organic crosslinking agent after crosslinking with metal ions, polymeric microparticles, medical compositions, cosmetic compositions, medical articles and cosmetic articles comprising the same can be provided.
Claims18
A method of preparing polymeric microparticles comprising the steps of:
- subjecting a mixture containing a biocompatible polymer and a metal ion to a crosslinking reaction to form crosslinked polymer particles;
- and
- further crosslinking the crosslinked polymer particles in a polar solvent phase including an organic crosslinking agent containing at least one reactive functional group,
- wherein the biocompatible polymer comprises a mixture of hyaluronic acid and gelatin.
1 more element
Polymeric microparticles having a core-shell structure, comprising:
- a core including a first biocompatible polymer, a metal ion, and an organic crosslinking agent containing at least one reactive functional group;
- and
- a shell surrounding all or part of the core and including a second biocompatible polymer, a metal ion, and an organic crosslinking agent containing at least one reactive functional group, wherein the first biocompatible polymer comprises hyaluronic acid, and the second biocompatible polymer comprises gelatin.
Dependencies are inferred from the claim text.