Conjugates and their use as imaging agents
AssigneesCentenary Institute of Cancer Medicine and Cell Biology, The University of Sydney
InventorsPhilip Hogg, Ivan Ho Shon
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Abstract
The invention relates to compounds according to Formula (I): wherein A is —As(OH)2 or an arsenoxide equivalent group; each of R1, R2, R3 and R4 is independently selected from H, X, OH, NH2, CO, SCN, —CH2NH, —NHCOCH3, —NHCOCH2X or NO, and X is a halogen; R5 is —NHCH2COOH, OH or OR6, wherein R6 is a C1-5 straight or branched alkyl group; and Z is a radioisotope with a half-life of less than 4 days, or a pharmaceutically acceptable salt, ester, prodrug or solvate thereof, uses of said compounds, and methods of preparing said compounds. The invention also relates to diagnostic methods utilizing said compounds.
Claims19
A compound according to Formula (Ia)
- wherein A is —As(OH)2;
- and Z is selected from the group consisting of 64Cu, {Al18F}2+, 68Ga, and 99mTc;
- or a pharmaceutically acceptable salt or solvate thereof.
A compound according to Formula (IIa)
- wherein A is —As(OH)2 or an arsenoxide equivalent group;
- or a pharmaceutically acceptable salt, or solvate thereof.
Dependencies are inferred from the claim text.