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US 12,296,003 B2Granted
Bovine herpesvirus type 1 (BoHV-1) vector against bovine respiratory disease complex
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorShafiqul I. Chowdhury
Life of this patent
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Abstract
The application describes recombinant BoHV-1 triple mutant viruses that express protective antigens of other bovine respiratory viruses associated with Bovine respiratory disease complex (BRDC).
Claims25
A mutant BoHV-1 recombinant vector (BOHV-1) comprising at least one heterologous antigen inserted therein, wherein the mutant BoHV-1 vector has:
- a) a deletion of a cytoplasmic tail of envelope glycoprotein gE (gE-CT),
- b) a deletion of an entire Us9 envelope protein, and
- c) a deletion of the envelope protein UL49.5 residues 30-32, the cytoplasmic tail residues 80-96 or a combination thereof,
- wherein the at least one heterologous antigen is a BRSV F antigen having at least 95% amino acid sequence identity to SEQ ID NO:
- 15, 16, 17, 20, 22, or 24 or a BRSV G antigen having at least 95% amino acid sequence identity to SEQ ID NO:26, 28, 29, 31, 34, or 36, and
- wherein the BRSV F antigen or the BRSV G antigen is inserted in the mutant BOHV-1 recombinant vector at the gE-CT/Us9 deletion site.
3 more elements
Dependencies are inferred from the claim text.