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US 12,296,001 B2Granted
DNA vaccine against crimean-congo hemorrhagic fever virus (CCHFV)
AssigneeThe Wistar Institute of Anatomy and Biology
InventorsKar Muthumani, David Weiner
Life of this patent
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Abstract
Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Crimean-Congo hemorrhagic fever virus (CCHFV) antigens. Immunomodulatory methods and methods of inducing an immune response against CCHFV are disclosed. CCHFV glycoprotein immunogens are disclosed.
Claims14
A composition comprising:
- a nucleic acid molecule comprising a nucleotide sequence that encodes a consensus Crimean-Congo hemorrhagic fever virus (CCHFV) antigen wherein the antigen comprises the amino acid sequence selected from the group consisting of:
- a) SEQ ID NO:2, a fragment of SEQ ID NO:2 that comprises 600 or more consecutive amino acids;
- SEQ ID NO:2 linked to an IgE signal peptide, a fragment of SEQ ID NO:2 that comprises 600 or more consecutive amino acids linked to an IgE signal peptide;
- and
- b) SEQ ID NO:4, a fragment of SEQ ID NO:4 that comprises 600 or more consecutive amino acids, a fragment of SEQ ID NO:4 that comprises 600 or more consecutive amino acids linked to an IgE signal peptide.
2 more elements
Dependencies are inferred from the claim text.