Prostate neoantigens and their uses
AssigneeJanssen Biotech, Inc.
InventorsJason Lee DeHart, Vipul Bhargava, Manuel Alejandro Sepulveda
Life of this patent
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Abstract
Disclosed herein are self-replicating RNA molecules encoding prostate neoantigens, vaccines, and methods of treating and preventing prostate cancer.
Claims31
A self-replicating RNA molecule comprising an RNA encoding the polypeptides of SEQ ID NOs:
- 1001, 1003, 275, 381, 333, 337, 269, 253, 309, 325, 271, 305, 251, 245, 261, 265, 317, 255, 277, 297, 285, 437, 439, 442, 444, 379, 343, 211, 349, 213, 215, 221, 219, 225, 345, 353, 235, 223, 167, 171, 19, 23, and 177.
A polynucleotide encoding the polypeptides of SEQ ID NOs:
- 1001, 1003, 275, 381, 333, 337, 269, 253, 309, 325, 271, 305, 251, 245, 261, 265, 317, 255, 277, 297, 285, 437, 439, 442, 444, 379, 343, 211, 349, 213, 215, 221, 219, 225, 345, 353, 235, 223, 167, 171, 19, 23, and 177.
A method of treating a prostate cancer in a subject, the method comprising administering to the subject:
- a. a first vaccine comprising a polynucleotide encoding the polypeptides of SEQ ID NOs:
- 1001, 1003, 275, 381, 333, 337, 269, 253, 309, 325, 271, 305, 251, 245, 261, 265, 317, 255, 277, 297, 285, 437, 439, 442, 444, 379, 343, 211, 349, 213, 215, 221, 219, 225, 345, 353, 235, 223, 167, 171, 19, 23, and 177;
- and
- b. a second vaccine comprising a polynucleotide encoding the polypeptides of SEQ ID NOs:
- 1001, 1003, 275, 381, 333, 337, 269, 253, 309, 325, 271, 305, 251, 245, 261, 265, 317, 255, 277, 297, 285, 437, 439, 442, 444, 379, 343, 211, 349, 213, 215, 221, 219, 225, 345, 353, 235, 223, 167, 171, 19, 23, and 177.
A method of treating a prostate cancer in a subject, the method comprising administering to the subject a self-replicating RNA molecule comprising an RNA encoding the polypeptides of SEQ ID NOs:
- 1001, 1003, 275, 381, 333, 337, 269, 253, 309, 325, 271, 305, 251, 245, 261, 265, 317, 255, 277, 297, 285, 437, 439, 442, 444, 379, 343, 211, 349, 213, 215, 221, 219, 225, 345, 353, 235, 223, 167, 171, 19, 23, and 177.
Dependencies are inferred from the claim text.