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US 12,295,974 B2Granted
Compositions and methods for transplantation of colon microbiota
AssigneeRegents of the University of Minnesota
InventorsMichael J. Sadowsky, Alexander Khoruts, Alexa R. Weingarden, Matthew J. Hamilton
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Abstract
The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.
Claims9
A method of treating or preventing a recurrent Clostridium difficile infection in a subject in need thereof, the method comprising:
- receiving a pharmaceutical composition from a fecal microbiota supply bank,
- wherein the fecal microbiota supply bank comprises a plurality of fecal preparations,
- wherein each fecal preparation of the plurality comprises non-pathogenic fecal bacteria extracted via standardized processing from a stool of a screened human donor unrelated to the subject,
- wherein the pharmaceutical composition comprises saline, a cryoprotectant, and a single fecal preparation from the plurality of fecal preparations, and wherein the non-pathogenic fecal bacteria comprise bacteria of the phylum Firmicutes;
- and
- rectally administering the pharmaceutical composition to the subject, wherein the administering increases the relative abundance of one or more members of the phylum Firmicutes in the intestine of the subject by at least 5% compared to before the administering.
3 more elements
Dependencies are inferred from the claim text.