Methods of treating sepsis using anti-sepsis lipid a (ASLA) based therapeutics
AssigneeUniversity of Maryland, Baltimore
InventorsRobert K. Ernst, Erin M. Harberts, Alison J. Scott
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Abstract
The present invention provides a method of treating sepsis in a subject, comprising administering to the subject an effective amount of a compound of the formula wherein R1 and R2 may be H, OH, protonated phosphate, a phosphate salt, a sugar phosphonate, or a mono-, di- or poly-saccharide, R3 may be OH or a mono-, di- or poly-saccharide, R4, R5, R6 and R7 may be an alkyl or alkenyl chain of up to 13 carbons (for a chain of 16 carbons), and R8, R9, R10 and R11 may be H, OH, or an alkyl or alkenyl ester of up to 16 carbons, or a salt thereof.
Claims5
A method of treating and reducing the incidence and/or severity of sepsis sepsis in a subject, comprising administering to the subject an effective amount of a compound wherein the compound is selected from the group consisting of
- and combinations thereof.
Dependencies are inferred from the claim text.