Ascorbic acid and quinone compounds in combination with an antiparasitic agent for treating a parasitic disease
AssigneeIC-MedTech Corp.
InventorsSueli de Oliveira Silva Lautenschlager, Vania Cristina Desoti, Celso Vataru Nakamura, Valdecir Farias Ximenes
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Abstract
Provided herein is a method of treating, preventing, or alleviating one or more symptoms of Chagas disease in a subject, comprising administering to the subject: (i) ascorbic acid, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; (ii) a quinone compound, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof; and (iii) an antiparasitic agent.
Claims20
A method of treating or alleviating one or more symptoms of a parasitic disease in a subject, comprising administering to the subject:
- (i) ascorbic acid, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof;
- or a pharmaceutically acceptable salt thereof;
- (ii) a quinone compound, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof;
- or a pharmaceutically acceptable salt thereof;
- and (iii) an antiparasitic agent.
A method of inhibiting parasitic growth in, eliminating a parasite from, or increasing the quality of life of a subject infected with a parasite, comprising administering to the subject:
- (i) ascorbic acid, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof;
- or a pharmaceutically acceptable salt, solvate, or hydrate thereof;
- (ii) a quinone compound, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof;
- or a pharmaceutically acceptable salt thereof;
- and (iii) an antiparasitic agent.
A method of increasing the efficacy of an antiparasitic agent in, increasing tolerance to an antiparasitic agent in, reducing a side effect of an antiparasitic agent to, or reducing a toxicity of an antiparasitic agent to a subject infected with a parasite, comprising administering to the subject:
- (i) ascorbic acid, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof;
- or a pharmaceutically acceptable salt;
- and (ii) a quinone compound, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.