Preliminary diagnoses of cut tissue sections
AssigneeClarapath, Inc.
InventorsPartha P. Mitra, Charles R. Cantor, Baris Yagci, Steven Smith
Life of this patent
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Abstract
A system for optical interrogation of tissue samples, the system including: a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections including one or more tissue samples; a transfer medium configured to gather the one or more tissue sections and to transfer the one or more tissue sections to one or more slides; and an optical interrogation system including an illumination system configured to illuminate the one or more tissue sections and an imaging system configured to perform an imaging analysis on the one or more tissue sections illuminated with the illumination system.
Claims25
A system for optical interrogation of tissue samples, the system comprising:
- a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections comprising one or more tissue samples;
- an illumination system configured to illuminate the one or more tissue sections to optically stain the one or more tissue sections;
- an imaging system configured to obtain imaging data on the one or more tissue sections illuminated with the illumination system;
- and
- a processor being programmed to;
- perform an imaging analysis of the imaging data to determine a presence or an absence of a disease in the one or more tissue sections illuminated with the illumination system;
- and
- instruct the microtome to section one or more additional tissue sections for staining and imaging from the tissue block if there is a presence of the disease in the one or more tissue sections.
A system for optical interrogation of tissue samples, the system comprising:
- a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections comprising one or more tissue samples;
- an optical interrogation system comprising an illumination system configured to illuminate the one or more tissue sections to optically stain the one or more tissue sections and an imaging system configured to obtain imaging data indicative of intrinsic properties of the one or more tissue sections illuminated with the illumination system;
- and
- a processor in communication with the optical interrogation system, the processor being programmed to:
- receive the imaging data from the optical interrogation system and to determine a presence or an absence of a disease in the one or more tissue sections;
- and
- instruct the microtome to section one or more additional tissue sections for staining and imaging from the tissue block if there is a presence of the disease in the one or more tissue sections.
A method for optical interrogation of tissue samples, the method comprising:
- sectioning, using a microtome one or more tissue sections from a tissue block, one or more tissue sections comprising one or more tissue samples;
- illuminating, by an illumination system, the one or more tissue sections to optically stain the one or more tissue sections;
- performing, by an imaging system, an imaging analysis to collect imaging data on the one or more tissue sections illuminated by the illumination system;
- determining, by a processor and based on the imaging data, a presence or an absence of a disease in the one or more tissue sections;
- and
- sectioning, by the microtome, one or more additional tissue sections for staining and imaging from the tissue block if there is a presence of the disease in the one or more tissue sections.
A method for optical interrogation of tissue samples, the method comprising:
- sectioning, using a microtome one or more tissue sections from a tissue block, one or more tissue sections comprising one or more tissue samples;
- illuminating, by an illumination system, the one or more tissue sections to optically stain the one or more tissue sections;
- obtaining, by an imaging system, imaging data of the one or more tissue sections to collect imaging data on the one or more tissue sections illuminated by the illumination system;
- presenting the imaging data to a human user for determining a presence or an absence of a disease in the one or more tissue sections;
- and
- sectioning, using the microtome, one or more additional tissue sections for staining and imaging from the tissue block if there is a presence of the disease in the one or more tissue sections.
A system for optical interrogation of tissue samples, the system comprising:
- a microtome configured to section one or more tissue sections from a tissue block, the one or more tissue sections comprising one or more tissue samples;
- an illumination system configured to illuminate the one or more tissue sections to optically stain the one or more tissue sections;
- an imaging system configured to obtain imaging data on the one or more tissue sections illuminated with the illumination system;
- and
- a processor being programmed to:
- receive the imaging data;
- present the imaging data to a human user for determining a presence or an absence of a disease in the one or more tissue sections;
- and
- cause the microtome to section one or more additional tissue sections for staining and imaging from the tissue block if there is a presence of the disease in the one or more tissue sections.
Dependencies are inferred from the claim text.