Anti-matrix metalloproteinase 7 (MMP-7) inhibitory antibody and uses thereof
AssigneeYeda Research and Development Co. Ltd.
InventorsIrit Sagi, Vishnu Mohan
Life of this patent
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Abstract
A method of treating a disease associated with imbalanced or abnormal activity of MMP-7 is diclosed. The method comprises administration of an antibody comprising an antigen recognition region which binds a catalytic site of MMP-7, having complementarity determining region amino acid sequences as set forth in: SEQ ID NOs: 3, 4 and 5 (CDR3), sequentially arranged from N to C on a light chain of the antibody; and SEQ ID NOs: 6, 7 and 8, sequentially arranged from N to C on a heavy chain of the antibody.
Claims17
A method of treating a disease associated with imbalanced or abnormal activity of MMP-7 in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an antibody, having complementarity determining region amino acid sequences as set forth in:
- SEQ ID NOs:
- 3, 4 and 5, sequentially arranged from N to C on a light chain of the antibody;
- and SEQ ID NOs:
- 6 , 7 and 8, sequentially arranged from N to C on a heavy chain of the antibody, thereby treating the disease associate with imbalanced or abnormal activity of MMP-7 in the subject.
A method of treating cancer in a subject in need thereof comprising:
- (a) analyzing in a sample of the subject for an amount of MMP-7;
- and
- (b) administering to the subject a therapeutically effective amount of an antibody which having complementarity determining region amino acid sequences as set forth in:
- SEQ ID NOs:
- 3, 4 and 5, sequentially arranged from N to C on a light chain of the antibody;
- and SEQ ID NOs:
- 6, 7 and 8, sequentially arranged from N to C on a heavy chain of the antibody upon confirmation that said amount of said MMP-7 is above a predetermined level, thereby treating the cancer.
A method of treating cancer in a subject in need thereof comprising:
- (a) analyzing in a sample of the subject for an amount of MMP-7 using an antibody having complementarity determining region amino acid sequences as set forth in:
- SEQ ID NOs:
- 3, 4 and 5, sequentially arranged from N to C on a light chain of the antibody;
- and SEQ ID NOs:
- 6, 7 and 8, sequentially arranged from N to C on a heavy chain of the antibody;
- and
- (b) administering to the subject a therapeutically effective amount of an agent which down-regulates the amount of said MMP-7 upon confirmation that said amount of said MMP-7 is above a predetermined level, thereby treating the cancer.
A method of treating pancreatic cancer in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antibody which down-regulates MMP-7 activity and a chemotherapeutic agent, wherein the antibody inhibits the activity of said MMP-7 and wherein the Ki of the antibody towards said MMP-7 is at least 5 times lower than a Ki of the antibody towards MMP2 or MMP9, thereby treating the pancreatic cancer, wherein the antibody has complementarity determining region amino acid sequences as set forth in:
- SEQ ID NOs:
- 3, 4 and 5, sequentially arranged from N to C on a light chain of the antibody;
- and SEQ ID NOs:
- 6, 7 and 8, sequentially arranged from N to C on a heavy chain of the antibody.
An article of manufacture comprising an antibody, having complementarity determining region CDR amino acid sequences as set forth in:
- SEQ ID NOs:
- 3, 4 and 5, sequentially arranged from N to C on a light chain of the antibody;
- and SEQ ID NOs:
- 6, 7 and 8, sequentially arranged from N to C on a heavy chain of the antibody and a chemotherapeutic agent.
Dependencies are inferred from the claim text.