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US 12,291,567 B2Granted
Antibodies to granulocyte-macrophage colony stimulating factor and uses thereof
AssigneeElixiron Immunotherapeutics (Hong Kong) Limited
InventorsCheng-Lun Ku, Yu-Fang Lo, Han-Po Shih, Jing-Ya Ding, Pei-Han Chung, Yin-Ping Wang
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Abstract
Disclosed herein are anti-GM-CSF antibodies capable of binding to human GM-CSF and blocking its biological activities. Also provided herein are pharmaceutical compositions comprising the anti-GM-CSF antibodies and therapeutic and diagnostic uses of such antibodies.
Claims18
An isolated antibody, which binds to granulocyte-macrophage colony-stimulating factor (GM-CSF), wherein the antibody comprises:
- (a) a heavy chain variable domain (VH), which comprises a HC CDR1 of SEQ ID NO:
- 5, a HC CDR2 of SEQ ID NO:
- 6, and a HC CDR3 of SEQ ID NO:
- 7, and a light chain variable domain (VL), which comprises a LC CDR1 of SEQ ID NO:
- 8, a LC CDR2 of SEQ ID NO:
- 9, and a LC CDR3 of SEQ ID NO:
- 10;
- (b) a variant of the antibody set forth in (a), wherein one of HC CDR1, HC CDR2, HC CDR3, LC CDR1, or LC CDR3 is selected from
- (i) HC CDR1 of SEQ ID NO:
- 21 or 22,
- (ii) HC CDR2 of SEQ ID NO:
- 23,
- (iii) HC CDR3 of SEQ ID NO:
- 24, 25, 26 or 27;
- (iv) LC CDR1 of SEQ ID NO:
- 28,
- (v) LC CDR3 of SEQ ID NO:
- 29 or 30.
15 more elements
Dependencies are inferred from the claim text.