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US 12,291,559 B2Granted
Compositions and methods for treating cancer
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsDavid DiLillo, Thomas Craig Meagher
Life of this patent
Estimating the term…
Abstract
Disclosed are compositions and methods for targeted treatment of cancer. The present disclosure provides chimeric antigen receptors and cells expressing such chimeric antigen receptors. In certain embodiments, engineered cells expressing the chimeric antigen receptors are specific for a low density cancer antigen or peptide in groove antigen.
Claims15
A method of treating a tumor in a subject, the method comprising conjointly administering to the subject a first CAR polypeptide and a second CAR polypeptide, wherein the first CAR polypeptide comprises:
- a) at least one intracytoplasmic/costimulatory region comprising a cluster of differentiation 28 zeta (CD28/ζ) domain,
- b) at least one intracytoplasmic signaling region comprising a cluster of differentiation 3 zeta (CD3/ζ) domain, and
- c) an antigen binding domain comprising:
- (i) a light chain comprising SEQ ID NO:17 and a heavy chain comprising SEQ ID NO:
- 21;
- (ii) a light chain comprising SEQ ID NO:18 and a heavy chain comprising SEQ ID NO:
- 22;
- (iii) a light chain comprising SEQ ID NO:19 and a heavy chain comprising SEQ ID NO:
- 23;
- (iv) a light chain comprising SEQ ID NO:31 and a heavy chain comprising SEQ ID NO:
- 32;
- or
- (v) a light chain comprising SEQ ID NO:37 and a heavy chain comprising SEQ ID NO:
- 38, and the second CAR polypeptide comprises:
- a) a 4-1BB domain in the costimulatory region of the CAR polypeptide,
- b) at least one intracytoplasmic signaling region comprising a cluster of differentiation 3 zeta (CD3/ζ) domain, and
- c) an extracellular antigen binding domain comprising:
- (i) a light chain comprising SEQ ID NO:17 and a heavy chain comprising SEQ ID NO:
- 21;
- (ii) a light chain comprising SEQ ID NO:18 and a heavy chain comprising SEQ ID NO:
- 22;
- (iii) a light chain comprising SEQ ID NO:19 and a heavy chain comprising SEQ ID NO:
- 23;
- (iv) a light chain comprising SEQ ID NO:31 and a heavy chain comprising SEQ ID NO:
- 32;
- or
- (v) a light chain comprising SEQ ID NO:37 and a heavy chain comprising SEQ ID NO:
- 38.
25 more elements
Dependencies are inferred from the claim text.