US 12,291,527 B2 · Molecules that stimulate the immune system for treatment of drug addiction, methods of synthesis, antidrug vaccine and uses

Molecules that stimulate the immune system for treatment of drug addiction, methods of synthesis, antidrug vaccine and uses

AssigneesUniversidade Federal de Minas Gerais, Fundacao De Amparo A Pesquisa Do Estado De Minas Gerais-Fapemig

InventorsAngelo De Fatima, Frederico Duarte Garcia, Simone Odilia Antunes Fernandes, Valbert Nascimento Cardoso, Adriana Martins Godin, Angelica Faleiros Da Silva Maia, Leonardo Da Silva Neto, Maila De Castro Lourenco Das Neve, Paulo Sergio De Almeida Augusto

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Abstract

This technology relates to immune system stimulating molecules to be used in the treatment of drug addiction and abuse and their synthesis processes. These molecules have a calixarene chemical structure, preferably calix[4]arene and/or calix[8]arene, coupled to an hapten analogous to cocaine, preferably GNE and/or GNC. An anti-drug vaccine, specifically anti-cocaine, is also described using such molecules. The anti-drug vaccine can be also used to prevent fetal exposure to drugs in pregnant women who use drugs and do not wish or cannot stop their use during pregnancy.

Claims8

Dependent claims

An immune system stimulating molecule comprising a calixarene, wherein the calixarene is calix(4)arene or calix(8)arene, coupled to a hapten analogous to cocaine, the hapten being hapten GNE (6-(1R,2R,3S,5S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxamido-hexanoic acid) or hapten GNC (6-(((1R,2R,3S,5S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carbonyl)oxy)-hexanoic acid).

Dependencies are inferred from the claim text.

Facts

Application

16/633,696Filed 20 Jul 2018

Priority

BR 102017015955825 Jul 2017

Published

US 2020/0385376 A110 Dec 2020

Granted

6 May 2025

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Classification16 codes

C07D 451/12
Oxygen atoms: acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
A61K 31/46
Having six-membered rings with one nitrogen as the only ring hetero atom: 8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
A61K 39/0013
Medicinal preparations containing antigens or antibodies: therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
A61K 39/385
Medicinal preparations containing antigens or antibodies: haptens or antigens, bound to carriers