Galectin-3 inhibiting 2-hydroxycycloalkane-1-carbamoyl derivatives

A compound of formula (I)

• wherein
• n represents the integer 1 or 2;
• Ar1 represents
• aryl which is mono-, di-, tri-, tetra-, or penta-substituted, wherein the substituents are independently selected from halogen;
• methyl;
• cyano;
• methoxy;
• trifluoromethyl;
• and trifluoromethoxy;
• 5- or 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl independently is unsubstituted, mono-or di-substituted, wherein the substituents are independently selected from halogen, methyl, cyano, and methoxy;
• or
• 9- or 10-membered heteroaryl, wherein said 9- or 10-membered heteroaryl independently is unsubstituted, or mono-substituted with methyl;
• R1 represents
• hydroxy;
• C1-3-alkoxy;
• —O—CO—C1-3-alkyl;
• —O—CH2—CH2—OH;
• or
• —O—CH2—CO—OH;
• L represents a direct bond or methylene;
• and
• Ar2 represents
• phenyl, wherein said phenyl is unsubstituted, mono-, di-or tri-substituted wherein the substituents are independently selected from C1-6-alkyl, C3-6-cycloalkyl, —CH2-C3-6-cycloalkyl, C1-3-fluoroalkyl, C1-3-fluoroalkoxy, C1-3-alkoxy, halogen, and cyano;
• 5- or 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl independently is unsubstituted, mono-, di-, or tri-substituted wherein the substituents are independently selected from C1-6-alkyl, C3-6-cycloalkyl, —CH2-C3-6-cycloalkyl, C1-3-fluoroalkyl, C1-3-fluoroalkoxy, C1-3-alkoxy, halogen, and cyano;
• 9-membered bicyclic heteroaryl or 10-membered bicyclic heteroaryl, wherein said 9- or 10-membered bicyclic heteroaryl independently is unsubstituted, mono-or di-substituted, wherein the substituents are independently selected from methyl, methoxy, and halogen;
• or
• naphthyl;
• or a pharmaceutically acceptable salt thereof.