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US 12,290,575 B2Granted
Fluorescent compound comprising a fluorophore conjugated to a pH-triggered polypeptide
AssigneesUniversity of Rhode Island Board of Trustees, Yale University
InventorsYana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
Life of this patent
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Abstract
The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
Claims17
A method for removing diseased or damaged tissue in a subject, comprising:
- (a) administering a pH-triggered polypeptide fluorophore compound having the structure:
- (SEQ ID NO:
- 4) to the subject;
- (b) contacting the subject with electromagnetic radiation comprising an excitation wavelength of the fluorophore;
- (c) detecting electromagnetic radiation emitted from the compound, wherein detection of the radiation indicates the presence of the diseased or damaged tissue;
- and
- (d) surgically removing the diseased or damaged tissue identified by step (c).
4 more elements
A method for removing diseased or damaged tissue in a subject, comprising:
- (a) contacting a biological sample from a subject ex vivo with a pH-triggered polypeptide fluorophore compound having the structure:
- (SEQ ID NO:
- 4);
- (b) contacting the biological sample with electromagnetic radiation comprising an excitation wavelength of the fluorophore;
- and
- (c) detecting electromagnetic radiation emitted from the fluorophore, wherein detection of the radiation indicates the presence of the diseased or damaged tissue;
- and
- (d) surgically removing the diseased or damaged tissue identified by step (c) from the subject.
5 more elements
Dependencies are inferred from the claim text.