Compositions and methods for treatment of sepsis-related disorders
OwnerJohn Mansellinventor
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Abstract
A method comprising administering, to a subject in need thereof, an effective amount of a nucleotide effective to disrupt one or more pathways leading to sepsis. The nucleotide may be a nitric oxide disruptor effective to decrease the expression of inducible nitric oxide synthase. The nitric oxide disrupter may comprise a polynucleotide strand exhibiting at least 70% sequence identity to one of Sequence ID No. 1 through Sequence ID No. 47. Additionally or alternatively, the nucleotide may be an α disintegrin and metalloproteinase (ADAM) enzyme inhibitor effective to decrease the expression of ADAM enzyme. The ADAM enzyme inhibitor may comprise a polynucleotide strand exhibiting at least 70% sequence identity to one of Sequence ID No. 48 through Sequence ID No. 56.
Claims7
A method comprising administering an oligonucleotide effective to disrupt one or more pathways leading to sepsis to a subject, wherein the oligonucleotide is an α disintegrin and metalloproteinase (ADAMD) enzyme inhibitor, wherein the ADAM enzyme inhibitor is effective to decrease the expression of ADAM enzyme by at least 50%, wherein the ADAM enzyme inhibitor has a length of twenty-one nucleotides, and wherein the ADAM enzyme inhibitor comprises a polynucleotide strand exhibiting at least 70% sequence identity to one of Sequence ID No. 49 through Sequence ID No. 56.
Dependencies are inferred from the claim text.