Compositions and methods for treating epilepsy, seizures and other conditions

A method for treating a disease or disorder, or a symptom thereof, comprising orally administering a pharmaceutical composition directly without dilution to a patient in need thereof, wherein the pharmaceutical composition comprises:

• (a) topiramate, or a pharmaceutically acceptable addition salt thereof, in an amount of about 25 mg/ml;
• (b) polyethylene glycol in an amount of about 40% w/v to about 60% w/v;
• (c) glycerin in an amount of about 40% w/v to about 70% w/v;
• (d) one or more preservatives;
• and
• (e) optionally, one or more sweeteners, a flavor component comprising one or more flavor compounds, or a combination thereof;
• wherein the pharmaceutical composition is administered to the patient at 25 mg/ml of topiramate, or a pharmaceutically acceptable addition salt thereof, and
• wherein the disease or disorder, or symptom thereof, is selected from:
• epilepsy, partial-onset seizures, primary generalized tonic-clonic seizures, seizures associated with Lennox-Gastaut syndrome, and migraine.