Lint free crosslinked chitosan-PVA sponge as an absorbent wound dressing and method of preparation thereof

A process for the preparation of a cellular structured wound dressing consisting of the steps of:

• preparing an aqueous solution of polyvinyl alcohol (PVA) and preparing a solution of a biopolymer in acid/water mixture, followed by mixing the PVA solution with the biopolymer solution to obtain a blend,
• adding a plasticizer to the blend followed by adding a crosslinking agent and thoroughly mixing the same to obtain a final solution,
• subjecting said final solution to lyophilization to obtain a sponge,
• wherein lyophilization involves a step of freezing the blend in a range of −20° C. to −30° C. followed by drying with a temperature ramping at a rate of 4° C./min up to 40° C. to obtain cellular structured wound dressings;
• wherein the biopolymer is a chitosan having viscosity in the range from 200 to 2000CPS;
• the crosslinking agent is a salt of borate or polyphosphates or sulphates or sulphites or citric acid or a mixture thereof;
• and
• the plasticizer is glycerol;
• wherein the cellular structured wound dressing is with a density ranging from 0.5 g/cm3 to 6 g/cm3.