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US 12,286,456 B2Granted
Purification of virus like particles
AssigneeTakeda Vaccines, Inc.
InventorRoss Taylor
Life of this patent
Estimating the term…
Abstract
Methods of purifying virus-like particles (VLPs) that are substantially free of process contaminants and infectious agents. The methods incorporate, for example, low-pH treatment during harvest and/or inactivation by a solvent and/or detergent during VLP capture.
Claims23
A solution comprising a purified population of human norovirus Virus-Like Particles (VLPs), wherein the norovirus VLPs comprise at least genogroup II VLPs, wherein said solution contains no more than about 80% residual contaminating protein relative to said VLPs, and wherein the genogroup II VLPs comprise less than 1% VLPs with a truncated VP1 subunit.
Dependencies are inferred from the claim text.