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US 12,286,452 B2Granted
Amphiphilic aminoglycoside connexin hemichannel inhibitors
AssigneesTexas Tech University System, Utah State University
InventorsGuillermo A. Altenberg, Cheng-Wei Tom Chang
Life of this patent
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Abstract
The present invention includes novel molecules and methods of using an amphiphilic kanamycin molecule having substitutions at the O-4″, O-6″, or O-4″ and O-6″ positions having reduced antimicrobial activity for targeting Connexin Hemichannels.
Claims5
An amphiphilic molecule with a structure
- having reduced antimicrobial activity when compared to unmodified kanamycin;
- wherein
- Y is H2,
- Z is HR4,
- R1, R2, R3, R4 are, methyl, ethyl, propyl, butyl, linear alkyl, alkylcarbonyl chains, or cyclic groups.
2 more elements
A molecule of formula:
- wherein R in compounds 7b to 7h is selected from at least one of:
- R
- Compound
- 7b
- 7c
- 7d
- 7e
- 7f
- 7g
- 7h.
7 more elements
A molecule comprising the formula:
- wherein
- Code/compound #
- R
- K46B01/7
- Benzyl;
- K46BM5/8
- Benzyl and all hydroxyl groups were methylated;
- K46B09/10
- K46B03/11
- K46B10/12
- K46B04/13
- K46B05/14
- K46B11/15
- K46B07/16
11 more elements
A molecule having the formula:
Dependencies are inferred from the claim text.