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US 12,286,417 B2Granted
1,4-diazocane compound or salt thereof
AssigneeD. Western Therapeutics Institute, Inc.
InventorsKengo Sumi, Tomoyuki Koide, Osamu Kimata, Yuji Takashima, Kazunao Masubuchi
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Abstract
A method may produce an isoquinoline-6-sulfonamide derivative useful as a medicinal drug; and an intermediate which is used for the method, and more specifically, a 1,4-diazocane compound of formula (8), wherein R4 is an amino protecting group, or a salt thereof.
Claims2
A method for producing an isoquinoline-6-sulfonamide derivative of the following formula (11), optionally as a salt:
- the method comprising:
- reacting a 1,4-diazocane compound of the following formula (8), optionally as a salt:
- wherein R4 is an amino protecting group,
- with an isoquinoline-6-sulfonyl halide of the following formula (9), optionally as a salt:
- wherein X2 is a halogen atom;
- and
- then carrying out an elimination reaction of the amino protecting group.
4 more elements
Dependencies are inferred from the claim text.