Method for producing heterocyclidene acetamide derivative
AssigneeMochida Pharmaceutical Co., Ltd.
InventorsHideharu Uchida, Tsutomu Satoh, Bin Zhao, Xiaomin Gu, Jian Luo, Chuan Chen, Xiaofei Cai, Jiajie Ye, Jie Li, Fenglai Sun
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Abstract
The present invention provides, a novel method for producing a compound represented by formula (I) and a novel method for producing a compound represented by formula (B) or a salt thereof, which are intermediates in the production of formula (I).
Claims7
A method for producing a compound represented by Formula (I), the method comprising:
- asymmetrically reducing a keto group of a compound represented by Formula (SM8) to obtain a compound represented by Formula (A8);
- reacting the compound represented by Formula (A8) with ammonia water in the presence of a catalyst selected from the group consisting of Pd2(dba)3, PdCl2-Josiphos complex, CuI, Cu(OAc)2, Cu2O, CuO, CuBr, CuCl, CuSO4, and CuFe2O4 to obtain a compound represented by Formula (B);
- and
- causing a condensation reaction of the compound represented by Formula (B) or a salt thereof and a compound represented by Formula (CA-1) by using DMT-MM (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride) as a condensation agent to obtain the compound represented by Formula (I),
A method for producing a compound represented by Formula (I), the method comprising:
- reacting a compound represented by Formula (A8) with ammonia water in the presence of a catalyst selected from the group consisting of Pd2(dba)3, PdCl2-Josiphos complex, CuI, Cu(OAc)2, Cu2O, CuO, CuBr, CuCl, CuSO4, and CuFe2O4 to obtain a compound represented by Formula (B);
- and
- causing a condensation reaction of the compound represented by Formula (B) or a salt thereof and a compound represented by Formula (CA-1) by using DMT-MM (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride) as a condensation agent to obtain the compound represented by Formula (I),
A method for producing a compound represented by Formula (I), the method comprising:
- causing a condensation reaction of a compound represented by Formula (B) or a salt thereof and a compound represented by Formula (CA-1) by using DMT-MM (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride) as a condensation agent to obtain the compound represented by Formula (I),
A method for producing a compound represented by Formula (B), the method comprising:
- asymmetrically reducing a keto group of a compound represented by Formula (SM8) to obtain a compound represented by Formula (A8);
- and
- reacting the compound represented by Formula (A8) with ammonia water in the presence of a catalyst selected from the group consisting of Pd2 (dba)3, PdCl2-Josiphos complex, CuI, Cu(OAc)2, Cu2O, CuO, CuBr, CuCl, CuSO4, and CuFe2O4 to obtain the compound represented by Formula (B),
A method for producing a compound represented by Formula (B), the method comprising:
- reacting a compound represented by Formula (A8) with ammonia water in the presence of a catalyst selected from the group consisting of Pd2 (dba)3, PdCl2-Josiphos complex, CuI, Cu(OAc)2, Cu2O, CuO, CuBr, CuCl, CuSO4, and CuFe2O4 to obtain the compound represented by Formula (B),
A method for producing a compound represented by Formula (A8), the method comprising:
- asymmetrically reducing a keto group of a compound represented by Formula (SM8) to obtain the compound represented by Formula (A8),
Dependencies are inferred from the claim text.