Compounds and methods for treating cancer
AssigneeMayo Foundation for Medical Education and Research
InventorsJohn A. Copland, III, Han W. Tun, Thomas R. Caulfield, Christina Von Roemeling, Laura Ann Marlow
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Abstract
This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.
Claims20
A compound according to Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is an unsubstituted C1-6alkyl or C1-6haloalkyl;
- X is
- Y is selected from the group consisting of:
- m is 0 or 1;
- n is 0, 1, or 2;
- V is NR4 or O;
- R2, R3, and R4 are each independently H or an unsubstituted C1-6alkyl;
- and
- Z is an unsubstituted aryl.
Dependencies are inferred from the claim text.