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US 12,286,399 B2Granted
Synthesis of (R)(+)-2-(4-chloro-2-methyl phenoxy)propanoic acid in high enantiomeric excess
OwnerBomi Patel-Framrozeinventor
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Abstract
Provided herein is a process to react optical active chloroalkyl acid alkyl ester and substituted phenols in an aromatic solvent in the presence of a catalytic quantity of a quaternary ammonium salt to yield an optically active substituted phenoxy alkyl acid.
Claims7
A process of making an optically active substituted phenoxy alkyl acid comprising reacting an optically active chloroalkyl acid alkyl ester with a substituted phenol in an aromatic solvent in the presence of a catalytic quantity of a trialkyl benzyl ammonium halide salt.
Dependencies are inferred from the claim text.