Devices and methods for high-throughput screening of chemical and biochemical compounds

An article of manufacture, comprising:

• a sheet with an array of distinct and separate regions with respective chemical and/or biochemical compounds located thereon, the array of distinct and separate regions including:
• a first region with a first set of one or more chemical and/or biochemical compounds located thereon, wherein the first set of one or more chemical and/or biochemical compounds includes a particular compound;
• a second region, that is distinct and separate from the first region, with a second set of one or more chemical and/or biochemical compounds, that is distinct from the first set of one or more chemical and/or biochemical compounds, located thereon, wherein the second set of one or more chemical and/or biochemical compounds does not include the particular compound;
• and
• a third region, that is distinct and separate from the first region and the second region, with a third set of one or more chemical and/or biochemical compounds, that is distinct from the first set of one or more chemical and/or biochemical compounds and the second set of one or more chemical and/or biochemical compounds, located thereon,
• wherein:
• the sheet defines, for a respective region of the array of distinct and separate regions, one or more through-holes extending from one planar side of the sheet to an opposite planar side of the sheet and one or more connecting regions adjacent to the one or more through-holes so that the respective region is connected to a rest of the sheet by the one or more connecting regions;
• and
• each of the one or more connecting regions has a shape of a spoke connecting the respective region to the rest of the sheet, the one or more connecting regions arranged around the respective region.