A method for processing of biotechnological liquids, said method comprising passing a biotechnological liquid through a filter module, said filter module comprising a filter housing, and a filter, with a bundle of hollow fibres, and a centrifugal pump rotor in said filter housing, wherein an inlet flow path is defined such that the biotechnological liquid is flowable into the filter housing to the centrifugal pump rotor, the inlet flow path being perpendicular to a longitudinal axis of the filter, the inlet flow path is designed such that the biotechnological liquid flows into a hollow centre of the centrifugal pump rotor and the biotechnological liquid is deflected such that the biotechnological liquid thereafter flows parallel to the longitudinal axis of the filter and enters the hollow fibers of the filter by the centrifugal pump rotor forcing the biotechnological liquid into the hollow fibres, wherein the biotechnological liquid flows through the hollow fibres parallel to the longitudinal axis of the filter.