Hemostatic compositions and related methods
AssigneeBoston Scientific Scimed, Inc.
InventorsLauren Lydecker, Poorva Rajguru, David Wulfman, Joseph Rausa
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Abstract
Compositions including a plurality of particles that may be prepared from a chitosan salt and methods for preparing the same. The plurality of particles may have an average diameter ranging from about 100 μm to about 750 μm, such as from about 150 μm to about 500 μm; a steepness value ranging from about 30 to about 90; and an average aspect ratio greater than 0.6. The plurality of particles may be substantially spherical in shape, for example. Methods of preparation include electrospraying a chitosan salt solution through a needle.
Claims12
A method of preparing a composition, the method comprising:
- electrospraying a solution consisting essentially of a chitosan salt through a needle into an aqueous solution comprising a crosslinking agent to produce a plurality of particles comprising chitosan and the crosslinking agent;
- and
- freeze drying the plurality of particles;
- wherein the solution has a viscosity at 25° C. ranging from about 1,500 cPs to about 8,000 cPs;
- wherein the crosslinking agent comprises tripolyphosphate;
- wherein the plurality of particles have an average diameter ranging from about 100 μm to about 750 μm and an average aspect ratio ranging from about 0.6 to 1.0;
- and wherein the plurality of particles has a porosity greater than 80%, as measured by mercury intrusion porosimetry.
A method of preparing a composition, the method comprising:
- electrospraying a solution comprising a chitosan salt through a needle into an aqueous solution comprising a crosslinking agent to produce a plurality of particles consisting essentially of chitosan and the crosslinking agent;
- and
- freeze drying the plurality of particles;
- wherein the solution has a viscosity at 25° C. ranging from about 1,500 cPs to about 8,000 cPs;
- wherein the crosslinking agent comprises tripolyphosphate;
- wherein the plurality of particles have an average diameter ranging from about 300 μm to about 750 μm, an average aspect ratio ranging from about 0.6 to 1.0, and a bulk density ranging from about 0.1 g/ml to about 0.7 g/ml;
- and wherein the plurality of particles has a porosity greater than 80%, as measured by mercury intrusion porosimetry.
Dependencies are inferred from the claim text.