Trans-tympanic membrane delivery platform and uses thereof
AssigneeThe Medical College of Wisconsin, Inc.
InventorsAmit Joshi, Joseph Edward Kerschner, Wenzhou Hong, Gayatri Sharma
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Abstract
Provided herein are methods and composition for trans-tympanic membrane delivery of therapeutic agents such as antimicrobial agents, anti-inflammatory agents, and anti-biofilm agents to the middle ear for rapid, localized treatment and prevention of diseases and conditions associated with a middle ear infection. In particular, provided herein are cationic, anionic, and polymer-based nanoparticles that provide a platform for delivery of therapeutic cargo, as well as cationic, anionic, and polymer-based nanoparticles compositions for rapid, localized delivery of therapeutic agents to the middle ear.
Claims8
A pharmaceutical composition for preventing and alleviating otitis media, the composition comprising an aqueous suspension composition comprising cationic liposomes comprising a therapeutically effective amount of one or more therapeutic agents and a pharmaceutically acceptable aqueous carrier, wherein the cationic liposomes comprise 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), 3β-[N-(N′,N′-dimethylaminoethane)carbamoyl] cholesterol (DC-cholesterol), and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and have an average diameter size of about 50 nm to about 150 nm and a zeta potential from +25 mV to +50 mV,
- wherein, when topically applied to the tympanic membrane of the ear, the cationic liposomes diffuse through the ear's tympanic membrane, thereby delivering the one or more therapeutic agents to the middle or inner ear and treating the otitis media.
Dependencies are inferred from the claim text.