Bone targeted antimicrobial oxazolidinone related compounds, formulations thereof, and uses thereof

A compound according to Formula (1),

• wherein the Oxazolidinone is an oxazolidinone antimicrobial or antibiotic compound or agent, and the Oxazolidinone includes the structure
• to which the Linker is coupled, and
• wherein the Linker is a releasable linker that when coupled to the Oxazolidinone and the bisphosphonate (BP) forms a carbamate selected from the group consisting of an aryl carbamate, an O-thioaryl carbamate, an S-thioaryl carbamate, or a phenyl carbamate;
• wherein the aryl or phenyl group of the carbamate is coupled to the bisphosphonate (BP);
• and
• wherein the oxazolidinone antimicrobial or antibiotic compound or agent for coupling to the bisphosphonate (BP) by the Linker is selected from the group consisting of:
• linezolid, tedizolid, eperizolid, posizolid, radezolid, ranbezolid, and sutezolid, antimicrobial or antibiotic compounds and agents.