Compositions and methods for improving mitochondrial function

A method of treating Friedrich's Ataxia, the method comprising:

• administering to a subject at risk of or suffering from Friedrich's Ataxia, a therapeutically effective amount of a composition, thereby reducing the severity of at least one symptom of Friedrich's Ataxia compared to a subject without the administration, and
• wherein the composition comprises:
• a measured amount of a bacterial species that comprises and expresses nucleic acid sequences encoding membrane-bound PQQ-dependent glucose dehydrogenase (mGDH), ubiquinol-cytochrome c reductase iron-sulfur subunit, TonB-dependent receptor, carbon-nitrogen hydrolase, and ubiquinol oxidase subunit II, or an extract or fraction derived therefrom,
• wherein the extract or fraction of the bacterial species comprises membrane-bound PQQ-dependent glucose dehydrogenase (mGDH), ubiquinol-cytochrome c reductase iron-sulfur subunit, TonB-dependent receptor, carbon-nitrogen hydrolase, and ubiquinol oxidase subunit II expressed from the nucleic acid sequences,
• wherein the bacterial species is from the Acetobacteriaceae family.