Analyte sensor sensitivity attenuation mitigation

A system for monitoring analyte levels in a subject, comprising:

• an analyte sensor comprising a first working electrode and a plurality of second working electrodes configured to be positioned in contact with a fluid under a skin layer of a subject, wherein a size of each of the plurality of second working electrodes is smaller than a size than the first working electrode, wherein the plurality of second working electrodes are positioned to surround the first working electrode;
• and
• a data processing device communicatively coupled with the analyte sensor;
• and
• a receiving device communicatively coupled to the data processing device, wherein the receiving device comprises one or more processors and a memory operatively coupled to the one or more processors, the memory storing instructions which, when executed by the one or more processors, causes the receiving device to:
• receive a first signal indicative of one or more analyte levels measured by the first working electrode of the analyte sensor,
• receive a second signal indicative of the one or more analyte levels measured by the plurality of second working electrodes of the analyte sensor,
• detect a first dropout in an amplitude of the first signal measured by the first working electrode, the first dropout comprising a decrease in the amplitude of the first signal exceeding a rate of change threshold,
• compare the amplitude corresponding to the first dropout with a corresponding amplitude of the second signal from the analyte sensor to determine a first variation between the amplitude corresponding to the first dropout and the corresponding amplitude of the second signal,
• determine that the first variation is greater than a predetermined threshold difference between the amplitude of the first signal and the corresponding amplitude of the second signal,
• confirm, in response to determining that the first variation is greater than the predetermined threshold difference, that a portion of the first signal corresponding to the first dropout measured by the first working electrode of the analyte sensor is invalid,
• determine the one or more analyte levels based on the second signal, and
• display the determined one or more analyte levels on a display.

An apparatus for monitoring glucose levels in a subject, comprising:

• a glucose sensor comprising a first working electrode and a plurality of second working electrodes configured to be positioned in contact with a fluid under a skin layer of a subject, wherein a size of each of the plurality of second working electrodes is smaller than a size than the first working electrode, wherein the plurality of second working electrodes are positioned to surround the first working electrode;
• one or more processors;
• and
• a memory operatively coupled to the one or more processors and configured to store instructions which, when executed by the one or more processors, causes the one or more processors to:
• receive a first signal indicative of one or more glucose levels measured by the first working electrode of the glucose sensor,
• receive a second signal indicative of the one or more glucose levels measured by the plurality of second working electrodes of the glucose sensor,
• detect a first dropout in an amplitude of the first signal measured by the first working electrode, the first dropout comprising a decrease in the amplitude of the first signal exceeding a rate of change threshold,
• compare the amplitude corresponding to the first dropout with a corresponding amplitude of the second signal from the glucose sensor to determine a first variation between the amplitude corresponding to the first dropout and the corresponding amplitude of the second signal,
• determine that the first variation is greater than a predetermined threshold difference between the amplitude of the first signal and the corresponding amplitude of the second signal,
• confirm, in response to determining that the first variation is greater than the predetermined threshold difference, that a portion of the first signal corresponding to the first dropout measured by the first working electrode of the glucose sensor is invalid,
• determine the one or more glucose levels based on the second signal, and
• provide the determined one or more glucose levels for output on a display.