Use of mouse model in evaluation of intelligence level
AssigneeGempharmatech Co., Ltd.
InventorsCunxiang Ju, Jing Zhao, Jingjing Wang, Zhong Chen
Life of this patent
Estimating the term…
Abstract
A mouse model may be used in evaluation of the change in intelligence level. The mouse model may be a mouse model with high intelligence level. The mouse chromosome of the mouse model with high intelligence level at least includes all or a portion of chromosome 1 originated from wild-type mouse. The evaluation includes performing a test which may be an open field test, sucrose preference test, water maze test, space exploration Y maze test, active avoidance Y maze test, and/or fatigue rotarod test.
Claims5
A method for evaluating safety of a material using a D000765 mouse model, the method comprising:
- obtaining a resulting C57BL/6J mouse in which all or a portion of chromosome 1 is replaced by all or a portion of chromosome 1 from ZZ2 wild-type mouse;
- crossbreeding the resulting C57BL/6J mouse with C57BL/6J mouse in which chromosome 1 has not been replaced to produce a mouse in which chromosome 1 is heterozygous while the remainder chromosomes are homozygous;
- performing sibling selfing and screening by gene identification based on the mouse in which chromosome 1 is heterozygous while the remainder chromosomes are homozygous to obtain the D000765 mouse model, wherein the D000765 mouse model has increased learning ability, memory ability, and space exploration ability, when compared to a control wild-type C57BL/6J mouse;
- administering the material to the D000765 mouse model;
- determining whether the learning ability, memory ability, and space exploration ability of the D000765 mouse model is decreased after administration of the material, wherein a decrease in the learning ability, memory ability, and space exploration ability of the D000765 mouse model indicates that the material is not a safe material.
Dependencies are inferred from the claim text.