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US 12,281,356 B2Granted
Chemical compositions and methods of using same
AssigneeBruker Spatial Biology, Inc.
InventorsDwayne Dunaway, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang, Matthew Walsh, Gavin Meredith, Mark McElwain, Peter Skene, Cassandra Burke
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Abstract
The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
Claims19
A probe comprising:
- a target binding domain and a barcode domain;
- wherein the target binding domain is at least 12 nucleotides in length;
- wherein the barcode domain comprises a synthetic backbone, the barcode domain comprising at least two attachment positions, each attachment position comprising at least one attachment region comprising at least one nucleic acid sequence that hybridizes to a complementary nucleic acid molecule, and wherein the synthetic backbone comprises L-DNA,
- wherein each of the at least two attachment positions has a different nucleic acid sequence,
- wherein the at least two attachment positions correspond to the sequence of the target binding domain,
- wherein said nucleic acid sequence of each position of the at least two attachment positions determines the identity of the target nucleic acid that is bound by said target binding domain, and
- wherein each nucleotide of the at least one nucleic acid sequence of each attachment region is L-DNA.
4 more elements
Dependencies are inferred from the claim text.