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US 12,281,330 B2Granted
Adaptation of hollow-fiber-based cell culture technology for the manufacturing of (1) neo-islets, employed for the treatment of type 1 and type 2 diabetes mellitus, and (2) the generation of exosomes from various cell types, used in the treatment of different organ injuries and diseases
AssigneeSymbioCellTech, LLC
InventorsChristof Westenfelder, Anna L. Gooch
Life of this patent
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Abstract
Disclosed herein is a method of generating exosomes (extracellular nanovesicles) and/or neo-islets from mesenchymal or adipose stem cells or islets, or other cells in a Hollow-Fiber-based Cell Expansion (HFCE) System. Such exosomes and/or neo-islets may be used for the treatment of T1DM, T2DM, or associated microvascular disease.
Claims7
A method for generating Neo Islets, the method comprising:
- culturing expanding mesenchymal or adipose stem cells and pancreatic islet cells in a Hollow-Fiber-based Cell Expansion (HFCE) System;
- forming, in the HFCE system, Neo Islets from the cultured mesenchymal or adipose stem cells and pancreatic islet cells;
- and
- collecting the formed Neo Islets from the HFCE System.
1 more element
A method for generating Neo Islets, the method comprising:
- culturing expanding mesenchymal or adipose stem cells and pancreatic islet cells in a Hollow-Fiber-based Cell Expansion (HFCE) System;
- collecting exosomes from the HFCE System;
- forming, in the HFCE system, Neo Islets from the cultured mesenchymal or adipose stem cells and pancreatic islet cells;
- and
- collecting the formed Neo Islets from the HFCE System.
2 more elements
Dependencies are inferred from the claim text.