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US 12,281,307 B2Granted
Oligomers and oligomer conjugates
AssigneeHoffmann-La Roche Inc.
InventorsHassan Javanbakht, Søren Ottosen, Morten Lindow
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Abstract
The present invention relates to an oligomer conjugate for use in the treatment of a viral disorder. The oligomer conjugate comprises: a) an oligomer capable of modulating a target sequence in HBx and/or HBsAg of Hepatitis B Virus (HBV) to treat said viral disorder; and b) a carrier component capable of delivering the oligomer to the liver which is linked, preferably conjugated, to the oligomer.
Claims1
An oligomer conjugate suitable for use in the treatment of a viral disorder, wherein said oligomer conjugate comprises:
- a) at least one first oligomer region capable of modulating a target sequence of Hepatitis B Virus (HBV) to treat said viral disorder;
- and
- b) a carrier component;
- wherein said first oligomer region is 10-20 nucleotides in length;
- wherein said carrier component is a asialoglycoprotein receptor (ASGP-R) targeting moiety or a cholesterol conjugate moiety;
- and
- wherein said target sequence comprises at least part of a gene or a mRNA encoding HBx (SEQ ID NO:
- 1) or HBsAg (SEQ ID NO:
- 2) or a naturally-occurring variant thereof.
6 more elements
Dependencies are inferred from the claim text.