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US 12,281,073 B2Granted
Substituted piperidine compound and use thereof
AssigneeTakeda Pharmaceutical Company Limited
InventorsTatsuhiko Fujimoto, Kentaro Rikimaru, Koichiro Fukuda, Hiromichi Sugimoto, Takahiro Matsumoto, Norihito Tokunaga, Mariko Hirozane
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Abstract
Provided is a substituted piperidine compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as a prophylactic or therapeutic agent for narcolepsy.
Claims20
A compound having formula (III)
- wherein R2 is a cyclohexyl group substituted with a substituted phenyl group;
- wherein the phenyl group is substituted with a hydroxy group, an optionally substituted C1-6 alkoxy group, or a C7-16 aralkyloxy group.
A compound having formula (V)
- wherein R2 is a cyclohexyl group substituted with a substituted phenyl group;
- wherein the phenyl group is substituted with a hydroxy group, an optionally substituted C1-6 alkoxy group, or a C7-16 aralkyloxy group;
- and
- wherein R5 is an amino-protecting group.
1 more element
Dependencies are inferred from the claim text.