US 12,280,379 B2 · Molecular diagnostic assay system

Abstract

Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.

Claims9

Dependent claims

A system for operating a valve drive mechanism, the system comprising:

a valve drive mechanism chassis;
a brushless DC (BLDC) motor coupled to the chassis, wherein the BLDC motor comprises a plurality of hall-effect sensors and does not include any encoder hardware;
a transmission coupled to BLDC motor;
and
a valve drive coupled to the transmission, the valve drive configured to rotate positions of a valve body of a removable assay cartridge,
wherein position of the valve drive output is determined based on analyzing a sinusoidal signal generated by the hall-effect sensors, and
wherein the BLDC motor is configured to monitor cartridge integrity based a current measurements of a bridge circuit of the BLDC motor, the current draw measurements being associated with events indicating loss of integrity of the removable assay cartridge.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/054,729Filed 11 Nov 2022 · division

Priority

24 Jul 2015

Published

US 2023/0166263 A11 Jun 2023

Granted

22 Apr 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification33 codes

B01L 7/52
Heating or cooling apparatus ; Heat insulating devices: with provision for submitting samples to a predetermined sequence of different…
B01L 3/50273
By integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g.…
G01N 35/00871
Communications; Identification: communications between instruments or with remote terminals
G01N 35/1016
Characterised by arrangements for controlling the aspiration or dispense of liquids: control of the volume dispensed or introduced

Family

Application62/196,845Us provisional application · filed 24 Jul 2015

Application15/217,920Parent of this division · filed 22 Jul 2016

Application16/738,944Parent of this division · filed 9 Jan 2020

US 10,562,030 B2Parent of this division · filed 18 Feb 2020

US 2023/0166263 A1Pre-grant publication · published 1 Jun 2023

US 11,524,301 B2Parent of this division

US 2017/0021356 A1Published application

US 2020/0188922 A1Published application

US 12,280,379 B2This patent

From the US filing history. Foreign family members aren’t listed.

Molecular diagnostic assay system

Life of this patent

Molecular diagnostic assay system

Life of this patent

Abstract

Claims9