Counterpulsation device driver apparatus, method and system

A counterpulsation device (CPD) comprising:

• a blood chamber;
• a drive chamber;
• a membrane configured to separate the blood chamber from the drive chamber;
• a CPD drive line in pneumatic communication with the drive chamber;
• and
• a controller configured to:
• receive a heartbeat signal indicative of a heartbeat of a subject;
• control a pressure supplied to the CPD drive line to cause the CPD to alternately fill with blood and eject blood with a timing that is determined at least in part based on the heartbeat signal;
• receive a CPD drive line pressure signal indicative of the pressure in the CPD drive line;
• and
• adjust the pressure supplied to the CPD drive line based at least in part on the CPD drive line pressure signal, by performing at least one of:
• exposing the CPD drive line to a negative pressure to fill the blood chamber as the heart of the subject is contracting and exposing the CPD drive line to a positive pressure to empty the blood chamber as the heart of the subject is relaxing,
• wherein the controller is configured to adjust the pressure supplied to the CPD drive line based at least in part on the CPD drive line pressure signal by analyzing the CPD drive line pressure signal to determine a full condition or an empty condition of the CPD by analyzing change in drive line pressure as a function of time.