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US 12,280,120 B2Granted
Tumor-specific cleavable linkers
AssigneeXilio Development, Inc.
InventorsRaphael Rozenfeld, Ugur Eskiocak, Huawei Qiu, Parker Johnson, Kurt Allen Jenkins, Magali Pederzoli-Ribeil, Dheeraj Singh Tomar, Rebekah Kay O'Donnell
Life of this patent
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Abstract
The present disclosure provides tumor-specific cleavable linkers and their use in drugs and prodrugs for delivering therapeutics to a tumor cell environment. The present disclosure also provides cleavage products of said drugs and prodrugs, and methods related to the use of the same.
Claims11
A masked interleukin 12 (IL-12) cytokine comprising:
- a first polypeptide chain comprising a first Fc domain, and a masking moiety comprising the amino acid sequence of SEQ ID NO:
- 220;
- a second polypeptide chain comprising a second Fc domain, a first linker comprising a proteolytically cleavable peptide of SEQ ID NO:
- 249, and an IL-12 cytokine comprising an IL-12p40 polypeptide linked to an IL-12p35 polypeptide;
- and
- wherein the IL-12p40 polypeptide comprises the amino acid sequence of SEQ ID NO:
- 208 and the IL-12p35 polypeptide comprises the amino acid sequence of SEQ ID NO:
- 209.
5 more elements
A masked IL-12 cytokine comprising a first polypeptide chain comprising the amino acid sequence of SEQ ID NO:
- 192 and a second polypeptide chain comprising the amino acid sequence of SEQ ID NO:
- 195.
Dependencies are inferred from the claim text.