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AssigneeRNAimmune, Inc.
InventorsNeeti Ananthaswamy, Yong-Sik Bong, David Brown, Renxiang Chen, Ju Hyeong Jeon, Zhifeng Long, Dong Shen, Chun Lu, Patrick Y. Lu, Shenggao Tang, Jiaxi He, Ziyang He
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Provided herein is a ribonucleic acid (RNA) encoding a spike (S) protein or an immunogenic fragment thereof of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) comprising at least one non-naturally occurring amino acid mutation. In some embodiments, the S protein is derived from a delta variant. Additionally provided are relevant polynucleotides, vectors, cells, compositions, kits, production methods and methods of use.
A ribonucleic acid (RNA) encoding a spike(S) protein or an immunogenic fragment thereof of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), wherein the S protein or immunogenic fragment thereof comprises the polypeptide of SEQ ID NO:
A polynucleotide encoding a spike(S) protein or an immunogenic fragment thereof of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), wherein the polynucleotide encoding the S protein or immunogenic fragment thereof comprises the sequence of SEQ ID NO:
A polynucleotide encoding a spike(S) protein or an immunogenic fragment thereof of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), wherein the polynucleotide encoding the S protein or immunogenic fragment thereof comprises the sequence of SEQ ID NO:
Dependencies are inferred from the claim text.