Modified microorganisms expressing saga and related compositions for immunomodulation against infection and cancer immunotherapy
AssigneeThe Rockefeller University
InventorsHoward Hang, Matthew Griffin
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Abstract
Provided are compositions and methods based in part on the discovery that Enterococcus faecium secreted antigen A (SagA)-expressing bacteria are protective against enteric infections and enhances immune checkpoint inhibitor efficacy against cancer. Bacteria that express SagA or heterologous SagA, or orthologs thereof, are provided, and are included as nutraceutical, pharmaceutical, and probiotic formulations, as well as components of food products, including dairy products.
Claims7
Modified bacteria comprising that express a heterologous secreted antigen A (SagA) or an ortholog of SagA, said heterologous SagA having at least 80% sequence identity to SEQ ID NO:
- 1 and said ortholog having a NlpC/p60 hydrolase domain having at least 80% sequence identity to SEQ ID NO:
- 19, wherein the modified bacteria are Lactococcus lactis.
Dependencies are inferred from the claim text.