Pharmaceutical compounds and therapeutic methods

A complex comprising Zn2+ and a compound of formula (I):

• or a deuterated analog thereof, or an ion or poly-ion thereof, or a salt of said complex, wherein:
• R1 is morpholinomethyl, 2-morpholinoethyl, or (C1-C6)alkyl that is substituted with (C1-C6)alkoxy that is substituted with one or more groups independently selected from (C1-C6)alkoxy, halo, cyano, (C3-C6)cycloalkyl, (C2-C6)alkanoyloxy, (C2-C6)alkoxycarbonyl, and —N(Ra)2;
• R2 is selected from the group consisting of H, phenyl, heteroaryl, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, and (C3-C6)cycloalkyl, wherein any phenyl, heteroaryl, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, and (C3-C6)cycloalkyl is optionally substituted with one or more groups independently selected from halo, —N(Rb)2, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C2-C6)alkanoyloxy, (C2-C6)alkoxycarbonyl, (C2-C6)alkylaminocarbonyl, and (C2-C6)alkanoylamino;
• R3 and R4 are each independently selected from H, (C1-C6)alkyl, piperidinyl, or piperazinyl, which piperidinyl or piperazinyl is optionally substituted with pyridyl;
• or R3 and each R4 taken together with the nitrogen to which they are attached form a 3, 4, 5, 6, 7, 8, or 9 membered ring that is optionally substituted with one or more groups independently selected from the group consisting of halo;
• Y is S, O, or Se;
• each Ra is independently selected from the group consisting of H, (C1-C6)alkyl, (C3-C6)alkenyl, (C3-C6)alkynyl, (C3-C6)cycloalkyl, (C1-C6)alkanoyl, (C1-C6)alkylaminocarbonyl and (C1-C6)alkoxycarbonyl, wherein any (C1-C6)alkyl, (C3-C6)alkenyl, (C3-C6)alkynyl, (C3-C6)cycloalkyl, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, and (C1-C6)alkylaminocarbonyl, is optionally substituted with one or more groups independently selected from halo, (C3-C6)cycloalkyl, and (C1-C6)alkoxy;
• or two Rª taken together with the nitrogen to which they are attached form an azetidino, pyrrolidino, piperidino, or morpholino ring;
• and
• each Rb is independently selected from the group consisting of H, (C1-C6)alkyl, (C3-C6)alkenyl, (C3-C6)alkynyl, (C3-C6)cycloalkyl, (C1-C6)alkanoyl, (C1-C6)alkylaminocarbonyl and (C1-C6)alkoxycarbonyl, wherein any (C1-C6)alkyl, (C3-C6)alkenyl, (C3-C6)alkynyl, (C3-C6)cycloalkyl, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, and (C1-C6)alkylaminocarbonyl, is optionally substituted with one or more groups independently selected from halo, (C3-C6)cycloalkyl, and (C1-C6)alkoxy;
• or two Ra taken together with the nitrogen to which they are attached form an azetidino, pyrrolidino, piperidino, or morpholino ring.