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US 12,280,023 B2Granted
Fluorophenyl beta-hydroxyethylamines and their use in the treatment of hyperglycaemia
AssigneeAtrogi AB
InventorsBenjamin Pelcman, Tore Bengtsson
Life of this patent
Estimating the term…
Abstract
There is herein provided a compound of formula (I).
Claims28
A compound of formula IB
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 represents C4-12 alkyl optionally substituted by one or more halo;
- R2 and R3 each independently represent H or C1-3 alkyl optionally substituted by one or more halo;
- or R2 and R3 may be linked together to form, together with the carbon atom to which they are attached, a 3- to 6-membered ring, which ring optionally is substituted by one or more groups independently selected from halo and C1 alkyl optionally substituted by one or more halo;
- X represents Cl, Br, Ra, —CN, —N3, —N(Rb)Rc, —NO2, —ONO2, —ORd, —S(O)pRe or —S(O)qN(Rf)Rg;
- Ra represents C1-6 alkyl optionally substituted by one or more groups independently selected from G;
- each Rb, Rc, Rd, Re, Rf and R independently represents H or C1-6 alkyl optionally substituted by one or more groups independently selected from G;
- or alternatively any of Rb and Rc and/or Rf and Rg may be linked together to form, together with the nitrogen atom to which they are attached, a 4- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from halo, C1-3 alkyl optionally substituted by one or more halo, and ═O;
- G represents halo, —CN, —N(Ra1)Rb1, —ORc1, —S(O)pRd1, —S(O)qN(Re1)Rf1 or ═O;
- each Ra1, Rb1, Rc1, Rd1, Re1 and Rf1 independently represents H or C1-6 alkyl optionally substituted by one or more halo;
- or alternatively any of Ra1 and Rb1 and/or Re1 and Rf1 may be linked together to form, together with the nitrogen atom to which they are attached, a 4- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from halo, C1-3 alkyl optionally substituted by one or more halo, and ═O;
- m represents 2;
- n represents 1;
- each p independently represents 0, 1 or 2;
- and
- each q independently represents 1 or 2,
- wherein alkyl groups may be straight-chain or, when there is a sufficient number of carbon atoms, be branched-chain, and/or cyclic or part cyclic.
14 more elements
A pharmaceutical composition comprising a compound of Formula (IB)
- or a pharmaceutically acceptable salt thereof, and optionally one or more pharmaceutically acceptable adjuvant, diluent and/or carrier,
- wherein:
- R1 represents C4-12 alkyl optionally substituted by one or more halo;
- R2 and R3 each independently represent H or C1-3 alkyl optionally substituted by one or more halo;
- or R2 and R3 may be linked together to form, together with the carbon atom to which they are attached, a 3- to 6-membered ring, which ring optionally is substituted by one or more groups independently selected from halo and C1 alkyl optionally substituted by one or more halo;
- each X independently represents Cl, Br, Ra, —CN, —N3, —N(Rb)Rc, —NO2, —ONO2, —ORd, —S(O)pRe or —S(O)qN(Rf) Rg;
- Ra represents C1-6 alkyl optionally substituted by one or more groups independently selected from G;
- each Rb, Rc, Rd, Re, Rf and Rg independently represents H or C1-6 alkyl optionally substituted by one or more groups independently selected from G;
- or alternatively any of Rb and Rc and/or Rf and Rg may be linked together to form, together with the nitrogen atom to which they are attached, a 4- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from halo, C1-3 alkyl optionally substituted by one or more halo, and ═O;
- G represents halo, —CN, —N(Ra1)Rb1, —ORc1, —S(O)pRd1, —S(O)qN(Re1)Rf1 or ═O;
- each Ra1, Rb1, Rc1, Rd1, Re1 and Rf1 independently represents H or C1-6 alkyl optionally substituted by one or more halo;
- or alternatively any of Ra1 and Rb1 and/or Re1 and Rf1 may be linked together to form, together with the nitrogen atom to which they are attached, a 4- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from halo, C1-3 alkyl optionally substituted by one or more halo, and ═O;
- m represents 2;
- n represents 0 to 4;
- each p independently represents 0, 1 or 2;
- and
- each q independently represents 1 or 2,
- wherein alkyl groups may be straight-chain or, when there is a sufficient number of carbon atoms, be branched-chain, and/or cyclic or part cyclic.
15 more elements
Dependencies are inferred from the claim text.