Method for making superparamagnetic iron oxide nanocarrier
AssigneeImam Abdulrahman Bin Faisal University
InventorsB. Rabindran Jermy, Vijaya Ravinayagam
Life of this patent
Estimating the term…
Abstract
Silica nanocarriers hybridized with superparamagnetic iron oxide nanoparticles (“SPIONs”) and curcumin through equilibrium or enforced adsorption technique. Methods for dual delivery of SPIONs and curcumin to a target for diagnosis or therapy, for example, for SPION-based magnetic resonance imaging or for targeted delivery of curcumin to a cell or tissue. The technique can be extend to co-precipitation of mixed metal oxide involving Ni, Mn, Co and Cu oxide. The calcination temperature can be varied from 500-900° C. The nanocombination is functionalized with chitosan, polyacrylic acid, PLGA or another agent to increase its biocompatibility in vivo.
Claims13
A method for making a superparamagnetic iron oxide nanocarrier, comprising:
- drying a nanoporous structured silica under vacuum to form a platform of nanoporous structured silica;
- impregnating nanostructured pore surfaces of the platform of nanoporous structured silica with superparamagnetic iron oxide nanoparticles (SPIONs) to form an impregnated platform of structured silica, wherein the impregnating includes:
- mixing the platform of nanoporous structured silica with iron nitrate to form an iron precursor;
- drying the iron precursor to form the impregnated platform of structured silica;
- and
- calcining the impregnated platform of structured silica between 500 and 900° C. to form a calcined platform of structured silica and magnetic particles, and
- adsorbing a curcuminoid onto the calcined platform of structure silica and magnetic nanoparticles to form the superparamagnetic iron oxide nanocarrier, wherein the adsorbing includes:
- mixing the calcined platform of structured silica and magnetic nanoparticles with an aqueous solution of the curcuminoid,
- wherein the superparamagnetic iron oxide nanocarrier comprises at least one nanoporous structured silica selected from the group consisting of SiSBA-16, Q-10 silica, mesocellular foam, silicalite, mesosilicalite, SiKIT-6, ULPFDU-12, SiMCM-41, ZSM-5, USY, Mordenite, ZSM-11, ZSM-12, ZSM-22, ZSM-23, and mixtures thereof,
- wherein the superparamagnetic iron oxide nanoparticles are present in an amount ranging from about 5 wt % to about 30 wt % based on total weight of the superparamagnetic iron oxide nanocarrier, and
- wherein the curcuminoid is adsorbed on the surface of the nanoporous structured silica.
Dependencies are inferred from the claim text.