Catheter for cardiac and renal nerve sensing and mediation

A system comprising:

• an external mapping station;
• and
• an electrophysiology catheter for combination with the external mapping station comprising:
• a handle forming a proximal portion of the electrophysiology catheter;
• a flexible sheath forming an intermediary portion of the electrophysiology catheter, the flexible sheath forming a communication channel;
• a movable catheter tip forming a distal portion of the electrophysiology catheter;
• wherein the handle includes circuitry for processing digital data signals received from the catheter tip via the communication channel and for providing power to the catheter tip via the communication channel, the handle being configured to control movement of the catheter tip;
• wherein the catheter tip includes an electrode region forming a most distal portion of the catheter tip, a circuitry region forming a least distal portion of the catheter tip, and a flexible bending region between the electrode region and the circuitry region, the catheter tip further comprising:
• a plurality of electrodes disposed in an electrode region in a most distal portion of the catheter tip;
• one or more multiplexers disposed in the circuitry region and in communication with the plurality of electrodes, the one or more multiplexers being configured to combine tissue-based electrophysiological signals received at the plurality of electrodes;
• amplification circuitry disposed in the circuitry region and in communication with the one or more multiplexers, the amplification circuitry being configured to amplify the combined tissue-based electrophysiological signals;
• digitizing circuitry disposed in a circuitry region and in communication with the amplification circuitry, the digitizing circuitry being configured to digitize the amplified and combined tissue-based electrophysiological signals;
• and
• controller circuitry disposed in the circuitry region and in communication with the digitizing circuitry, the controller circuitry being configured to create and communicate the digital data signals containing the digitized, amplified and combined tissue-based electrophysiological signals to the circuitry in the handle of the electrophysiology catheter via the communication channel in the flexible sheath of the electrophysiology catheter.