Back to results
US 12,279,600 B2Granted
Genetically modified sterile avians and method for the reconstitution thereof
AssigneeThe University Court of the University of Edinburgh
InventorsMike McGrew, Mark Woodcock
Life of this patent
Estimating the term…
Abstract
Disclosed herein transgene construct comprising (i) a first nucleotide sequence, wherein the activity of the protein encoded by said first nucleotide sequence causes death of germ cells in the presence of an exogenous induction agent and (ii) a second nucleotide sequence which targets said construct to avian germ cells, methods of using the same and a transgenic avian provided by such methods.
Claims11
A transgene construct comprising:
- (i) a first nucleotide sequence, wherein said first nucleotide sequence encodes an apoptosis inducing enzyme, wherein said apoptosis inducing enzyme is inducible Caspase9 (iCaspase9), wherein the activity of the protein encoded by said first nucleotide sequence causes death of germ cells in the presence of an exogenous induction agent;
- and
- (ii) a second nucleotide sequence which targets said construct to avian germ cells, wherein said second nucleotide sequence targets the genetic DAZL locus.
Dependencies are inferred from the claim text.