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US 12,276,670 B2Granted
Methods for identifying and treating adrenomyeloneuropathy (AMN)
AssigneeThe General Hospital Corporation
InventorsFlorian Eichler, Yi Gong
Life of this patent
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Abstract
Provided herein is a method of detecting adrenomyeloneuropathy (AMN) in a human male subject, said method comprising determining the level of MFGE8, C1qa, Trem2, Gas6 or any combination thereof, in a biological sample obtained from the spine of the subject, wherein said level or levels are increased compared to a reference level or levels, thereby detecting AMN in the subject. Also provided is a method of treating AMN in a human male subject, said method comprising administering an anti-MFGE8 antibody to the subject.
Claims9
A method, comprising:
- providing a biological sample from a spine of a human male subject diagnosed with X-linked adrenoleukodystrophy (X-ALD), and
- detecting a level of milk fat globule-EGF factor 8 (MFGE8), complement C1q A chain (C1qa), triggering receptor expressed on myeloid cells 2 (Trem2), or growth arrest specific 6 (Gas6), in the sample.
Dependencies are inferred from the claim text.