Methods for screening and identifying agents that inhibit or modulate the nuclear egress complex of herpesviruses

A polypeptide comprising at least two fused domains, wherein

• a) a first domain comprises a polypeptide comprising amino acid residues 1 to 171 according to SEQ ID NO:
• 1 or according to SEQ ID NO:
• 2, or a homologue thereof, and wherein a second domain comprises a polypeptide comprising amino acid residues 180 to 413 according to SEQ ID NO:
• 1 or amino acid residues 180 to 208 according to SEQ ID NO:
• 2, or a homologue thereof;
• or
• b) a first domain comprises a polypeptide comprising amino acid residues 1 to 192 according to SEQ ID NO:
• 3 or according to SEQ ID NO:
• 4, or a homologue thereof, and wherein a second domain comprises a polypeptide comprising amino acid residues 198 to 438 according to SEQ ID NO:
• 3 or amino acid residues 198 to 230 according to SEQ ID NO:
• 4, or a homologue thereof;
• or
• c) a first domain comprises a polypeptide comprising amino acid residues 1 to 174 according to SEQ ID NO:
• 5 or according to SEQ ID NO:
• 6, or a homologue thereof, and wherein a second domain comprises a polypeptide comprising amino acid residues 183 to 439 according to SEQ ID NO:
• 5 or amino acid residues 183 to 215 according to SEQ ID NO:
• 6, or a homologue thereof.